Supine hypertension and progressive autonomic failure
نویسندگان
چکیده
منابع مشابه
Association between supine hypertension and orthostatic hypotension in autonomic failure.
Supine hypertension occurs commonly in primary chronic autonomic failure. This study explored whether supine hypertension in this setting is associated with orthostatic hypotension (OH), and if so, what mechanisms might underlie this association. Supine and upright blood pressures, hemodynamic responses to the Valsalva maneuver, baroreflex-cardiovagal gain, and plasma norepinephrine (NE) levels...
متن کامل[Orthostatic hypotension and supine hypertension in primary autonomic failure. Pathophysiology, diagnosis and treatment].
There are three diseases classified as primary autonomic failure (PAF), multiple system atrophy, Parkinson's disease, pure autonomic failure. Compensatory mechanisms preventing from decrease in blood pressure are inefficient in PAF. Among half of the patients with PAF occur orthostatic hypotension (OH) and supine hypertension (SH), which are the cause of deterioration of life quality. The treat...
متن کاملClonidine for the treatment of supine hypertension and pressure natriuresis in autonomic failure.
Patients with autonomic failure are disabled by orthostatic hypotension, which can be worsened by the nighttime pressure natriuresis induced by associated supine hypertension. Several pharmacological agents are available that effectively reduce nighttime hypertension, but none of them prevent pressure natriuresis. Because hypertension of autonomic failure can be driven by residual sympathetic t...
متن کاملMineralocorticoid Receptor Activation Contributes to the Supine Hypertension of Autonomic Failure.
Primary autonomic failure is characterized by disabling orthostatic hypotension, but at least half of these patients have paradoxical supine hypertension. Renin-angiotensin mechanisms were not initially thought to contribute to this hypertension because plasma renin activity is often undetectable in autonomic failure. Plasma aldosterone levels are normal, however, and we recently showed that pl...
متن کاملSympathetically mediated hypertension in autonomic failure.
BACKGROUND Approximately 50% of patients with primary autonomic failure have supine hypertension. We investigated whether this supine hypertension could be driven by residual sympathetic activity. METHODS AND RESULTS In patients with multiple system atrophy (MSA) or pure autonomic failure (PAF), we studied the effect of oral yohimbine on seated systolic blood pressure (SBP), the effect of gan...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2000
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(00)00907-9